Plant products with acetylcholinesterase inhibitory activity for insect control

Acetylcholinesterase (AChE) inhibitors are widely used in Alzheimer’s treatment, but they also crucial for their action on organophosphorus insecticides. The latter exert toxicity by inhibiting the AChE enzyme insects, leading to death. Amaryllidaceae alkaloids have been proven be potent inhibitors. In present study methanolic extracts and essential oils being obtained from species of Asteraceae, Lamiaceae, Brassicaceae were evaluated vitro inhibitory activity. Ellman’s colourimetric method, with modifications, was activity evaluation. According level, tested plant products divided into three categories. First: strong comparable that galanthamine; second: medium activity, IC 50 value about 1 mg/ml last group low greater than mg/ml. Essential Origanum vulgare subsp. hirtum Ietswaart., Satureja pilosa Vel., Monarda fistulosa L., Thymus longedentatus (Degen & Urum.) Ronniger extract Leucojum aestivum L. showed most referred as first group. Carvacrol identified main component active oils. extract, galanthamine found alkaloid. results indicate alkaloid-rich possess strongest This gives us a reason recommend these insecticidal future.